Serious and sometimes fatal adverse reactions occurred with TECENTRIQ treatment. Warnings and precautions include severe and fatal immune-mediated adverse reactions, including pneumonitis, colitis, hepatitis, endocrinopathies, dermatologic adverse reactions, nephritis with renal dysfunction, and solid organ transplant rejection. Other warnings and precautions include infusion-related reactions, complications of allogeneic HSCT, and embryo-fetal toxicity.
Please see below and the TECENTRIQ Prescribing Information for additional Important Safety Information.
BSC=best supportive care; CI=confidence interval; HR=hazard ratio; HSCT=hematopoietic stem cell transplantation; NE=not estimable; NSCLC=non-small cell lung cancer; OS=overall survival; PD-L1=programmed death-ligand 1.
*Stratified by disease stage, sex, and histology.
TC=tumor cells.
†No formal hypothesis testing was conducted for these subgroups.
‡Unstratified HRs are reported.
ALK=anaplastic lymphoma kinase; ECOG=Eastern Cooperative Oncology Group; EGFR=epidermal growth factor receptor; ITT=intent to treat; PS=performance status.
*Stratified by disease stage, sex, and histology.
§89% and 81% of patients in the ITT population with unknown EGFR or ALK status, respectively, had squamous NSCLC and were not required to undergo local or central testing.
TECENTRIQ Prescribing Information. Genentech, Inc.
TECENTRIQ Prescribing Information. Genentech, Inc.
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Felip E, Altorki N, Zhou C, et al; IMpower010 Investigators. Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial. Lancet. 2021;398:1344-1357.
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Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Small Cell Lung Cancer V.10.2024. © National Comprehensive Cancer Network, Inc. 2024. All rights reserved. Accessed September 23, 2024. To view the most recent and complete version of the guideline, go online to www.NCCN.org.
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VENTANA PD-L1 (SP263) Assay Interpretation Guide for Non-Small Cell Lung Cancer 1% and 50% Tumor Cell (TC) Scoring Algorithm. Ventana Medical Systems, Inc. publication 1020383US Rev B. Updated 2023.
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Data on file. Genentech Inc.
Data on file. Genentech Inc.
Data on file. Roche.
Data on file. Roche.
TECENTRIQ HYBREZA Prescribing Information. Genentech, Inc.
TECENTRIQ HYBREZA Prescribing Information. Genentech, Inc.
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